Solid Lipid Nanoparticles Coated with Glucosylated poly(2-oxazoline)s: A Supramolecular Toolbox Approach.Elter JK, Sedlák F, Palušák T, Bernardová N, Lobaz V, Tihlaříková E, Neděla V, Šácha P, Hrubý M. Biomacromolecules. 2025 Jan 8. doi: 10.1021/acs.biomac.4c01052.
Nuclear patterns of phosphatidylinositol 4,5‑ and 3,4‑bisphosphate revealed by super‑resolution microscopy differ between the consecutive stages of RNA polymerase II transcription. Hoboth P, Sztacho M, Hozák P. FEBS J. 2024 Oct;291(19):4240‑4264. doi: 10.1111/febs.17136.
The perinucleolar compartment and the oncogenic super-enhancers are part of the same phase-separated structure filled with phosphatidylinositol 4,5bisphosphate and long noncoding RNA HANR. Miladinović A, Antiga L, Venit T, Bayona-Hernandez A, Červenka J, Labala RK, Kolář M, Castaño E, Sztacho M, Hozak P. Adv Biol Regul. 2024 Nov 30:101069. doi: 10.1016/j.jbior.2024.101069.
Modified live vaccine strains of porcine reproductive and respiratory syndrome virus cause immune system dysregulation similar to wild strains.Stepanova K, Toman M, Sinkorova J, Sinkora S, Pfeiferova S, Kupcova Skalnikova H, Abuhajiar S, Moutelikova R, Salat J, Stepanova H, Nechvatalova K, Leva L, Hermanova P, Kratochvilova M, Dusankova B, Sinkora M Jr, Horak V, Hudcovic T, Butler JE, Sinkora M. Front Immunol. 2024 Jan 12; doi: 10.3389/fimmu.2023.1292381. PMCID: PMC10811158.
Iridium-based Polymeric Multifunctional Imaging Tools for Biochemistry. Sansee A, Kostka L, Marcalíková A, Kudláčová J, Sedlák F, Kotrchová L, Šácha P, Etrych T, Kielar F. Chempluschem. 2024 May;89(5):e202300647. doi: 10.1002/cplu.202300647.
Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkers. Ananbeh, H., Kupcova Skalnikova, H. (2023). . In: Thomas, E.A., Parkin, G.M. (eds) Biomarkers for Huntington's Disease. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-031-32815-2_3
Microtubule-associated NAV3 regulates invasive phenotypes in glioblastoma cells. Skarkova A, Pelantova M, Tolde O, Legatova, Mateu R, Bušek P, Garcia-Borja E, Sedo A, Etienne-Manneville S, Rosel D, Brábek J. Brain Pathology. 2024. e13294. https://doi.org/10.1111/bpa.13294
Fibrillar extracellular matrix produced by pericyte-like cells facilitates glioma cell dissemination. Vymola P, Garcia-Borja E, Cervenka J, Balaziova E, Vymolova B, Veprkova J, Vodicka P, Skalnikova H, Tomas R, Netuka D, Busek P, Sedo A. Brain Pathol. 2024 May 5:e13265. doi: 10.1111/bpa.13265. Epub ahead of print. PMID: 38705944.
The RNA‑dependent association of phosphatidylinositol 4,5‑bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization.Sztacho M, Červenka J, Šalovská B, Antiga L, Hoboth P, Hozák P. PLoS Genet. 2024 Dec 2;20(12):e1011462. doi: 10.1371/journal.pgen.1011462.
Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition. Sedlák F, Kvasnička A, Marešová B, Brumarová R, Dobešová D, Dostálová K, Šrámková K, Pehr M, Šácha P, Friedecký D, Konvalinka J. ACS Chem Neurosci. 2024 Apr 3;15(7):1342-1355. doi: 10.1021/acschemneuro.3c00494.
Molecularly targeted protease-activated probes for visualization of glioblastoma: a comparison with 5-ALA. Konečná D, Výmola P, Ternerová N, Výmolová B, Garcia-Borja E, Mateu R, Šroubek F, Pankrác J, Widen JC, Bogyo M, Netuka D, Bušek P, Šedo J Neurosurg. 2024 Mar 29:1-12. doi: 10.3171/2024.1.JNS231137, PMID: 38552239.
Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells. Garcia-Borja E, Siegl F, Mateu R, Slaby O, Sedo A, Busek P, Sana J. Biomark Res. 2024 Feb 1;12(1):15. doi: 10.1186/s40364-024-00563-3. PMID: 38303021; PMCID: PMC10836005.
Tuning polymer-blood and polymer-cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers. Lobaz V, Liščáková V, Sedlák F, Musil D, Petrova SL, Šeděnková I, Pánek J, Kučka J, Konefał R, Tihlaříková E, Neděla V, Pankrác J, Šefc L, Hrubý M, Šácha P, Štěpánek P. Colloids Surf B Biointerfaces. 2023 doi: 10.1016/j.colsurfb.2023.113564.
Combination of quinoxaline with pentamethinium system: Mitochondrial staining and targeting. Kejík Z, Koubková N, Krčová L, Sýkora D, Abramenko N, Veselá K, Kaplánek R, Hajduch J, Houdová Megová M, Bušek P, Šedo A, Lacina L, Smetana K Jr, Martásek P, Jakubek M. Bioorg Chem. 2023 Dec;141:106816. doi: 10.1016/j.bioorg.2023.106816. Epub 2023 Sep 9. PMID: 37716274.
Fibroblast
activation protein as a potential theranostic target in brain metastases
of diverse solid tumours. Zubaľ M, Výmolová B, Matrasová I, Výmola P, Vepřková J, Syrůček M, Tomáš
R, Vaníčková Z, Křepela E, Konečná D, Bušek P, Šedo A. Pathology. 2023 Jun 16:S0031-3025(23)00137-X.
doi: 10.1016/j.pathol.2023.05.003. PMID: 37419841.
New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity. Talianová V, Kejík Z, Kaplánek R, Veselá K, Abramenko N, Lacina L, Strnadová K, Dvořánková B, Martásek P, Masařík M, Megová MH, Bušek P, Křížová J, Zdražilová L, Hansíková H, Vlčák E, Filimonenko V, Šedo A, Smetana K Jr, Jakubek M. Pharmaceutics. 2022 Aug 17;14(8):1712. doi: 10.3390/pharmaceutics14081712. PMID: 36015338; PMCID: PMC9416741.
Does DPP-IV Inhibition Offer New Avenues for Therapeutic Intervention in Malignant Disease? Busek P, Duke-Cohan JS, Sedo A. Cancers (Basel). 2022 Apr 21;14(9):2072. doi: 10.3390/cancers14092072. PMID: 35565202; PMCID: PMC9103952.
Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation.Gál P, Brábek J, Holub M, Jakubek M, Šedo A, Lacina L, Strnadová K, Dubový P, Hornychová H, Ryška A, Smetana K Jr. Histochem Cell Biol. 2022 Nov;158(5):415-434. doi: 10.1007/s00418-022-02140-x. Epub 2022 Jul 22. PMID: 35867145; PMCID: PMC9305064.
Fibroblast Activation Protein Expressing Mesenchymal Cells Promote Glioblastoma Angiogenesis.Balaziova E, Vymola P, Hrabal P, Mateu R, Zubal M, Tomas R, Netuka D, Kramar F, Zemanova Z, Svobodova K, Brabec M, Sedo A, Busek P. Cancers (Basel). 2021 Jul 1;13(13):3304. doi: 10.3390/cancers13133304. PMID: 34282761; PMCID: PMC8267680.
Regulation of Fibroblast Activation Protein by Transforming Growth Factor Beta-1 in Glioblastoma Microenvironment. Krepela E, Vanickova Z, Hrabal P, Zubal M, Chmielova B, Balaziova E, Vymola P, Matrasova I, Busek P, Sedo A. Int J Mol Sci. 2021 Jan 21;22(3):1046. doi: 10.3390/ijms22031046. PMID: 33494271; PMCID: PMC7864518.
Molecular recognition of fibroblast activation protein for diagnostic and therapeutic applications. Šimková A, Bušek P, Šedo A, Konvalinka J. Biochim Biophys Acta Proteins Proteom. 2020 Jul;1868(7):140409. doi: 10.1016/j.bbapap.2020.140409. Epub 2020 Apr 6. PMID: 32171757.
Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival.Sana J, Busek P, Fadrus P, Besse A, Radova L, Vecera M, Reguli S, Stollinova Sromova L, Hilser M, Lipina R, Lakomy R, Kren L, Smrcka M, Sedo A, Slaby O. Sci Rep. 2018 Feb 12;8(1):2836. doi: 10.1038/s41598-018-20929-6. PMID: 29434344; PMCID: PMC5809429.
Targeting fibroblast activation protein in cancer - Prospects and caveats. Busek P, Mateu R, Zubal M, Kotackova L, Sedo A. . Front Biosci (Landmark Ed). 2018 Jun 1;23(10):1933-1968. doi: 10.2741/4682. PMID: 29772538.
Fibroblasts potentiate melanoma cells in vitro invasiveness induced by UV-irradiated keratinocytes. Jobe NP, Živicová V, Mifková A, Rösel D, Dvořánková B, Kodet O, Strnad H, Kolář M, Šedo A, Smetana K Jr, Strnadová K, Brábek J, Lacina L. . Histochem Cell Biol. 2018 May;149(5):503-516. doi: 10.1007/s00418-018-1650-4. Epub 2018 Feb 12. PMID: 29435761.
Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein.Dvořáková P, Bušek P, Knedlík T, Schimer J, Etrych T, Kostka L, Stollinová Šromová L, Šubr V, Šácha P, Šedo A, Konvalinka J. J Med Chem. 2017 Oct 26;60(20):8385-8393. doi: 10.1021/acs.jmedchem.7b00767. Epub 2017 Oct 16. PMID: 28953383.
Heterogeneity of molecular forms of dipeptidyl peptidase-IV and fibroblast activation protein in human glioblastomas. Matrasova I, Busek P, Balaziova E, Sedo A. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Sep;161(3):252-260. doi: 10.5507/bp.2017.010. Epub 2017 Apr 26. PMID: 28452380.
Species-specific real-time RT-PCR analysis of expression of stromal cell genes in a tumor xenotransplantation model in mice. Krepela E, Busek P, Hilser M, Vanickova Z, Sedo A. . Biochem Biophys Res Commun. 2017 Sep 9;491(1):126-133. doi: 10.1016/j.bbrc.2017.07.061. Epub 2017 Jul 12. PMID: 28711492.
Early detection of sporadic pancreatic cancer: time for change.Frič P, Šedo A, Škrha J, Bušek P, Laclav M, Škrha P, Zavoral M. . Eur J Gastroenterol Hepatol. 2017 Aug;29(8):885-891. doi: 10.1097/MEG.0000000000000904. PMID: 28471824.